NAD+ is a remarkable anti-inflammatory and anti-aging supplement. Mice facing an excessive immune reaction called sepsis show improvement in their survival rate due to NAD+ supplement administration. When getting treated with NAD+, mice enduring the most advanced stage of sepsis, septic shock, demonstrate an 85% increase in their survival rates. NAD+ supplement lowers the levels of IL-6, a protein linked to aging, thus reducing inflammation in the body. Administering NAD plus supplement curtails the invasion of immune cells in various organs in a mouse model. Our bodies are fortified by an intricate defense mechanism, the immune system. This system works efficiently to shield us against various pathogens and bacterial invasions. Yet, as we age, this shield gets weaker with the progression of time. This leaves our bodies vulnerable to potentially fatal inflammatory responses against bacterial infections, such as sepsis. However, recent research conducted by scientists from the renowned Huntington Medical Research Institute and Harvard may hold the key to diminishing this possibly deadly immune reaction produced by our bodies. Septic Shock Death And NAD+ Supplement Benefits In an interesting study reported in a bioRXiv pre-print, Iske and colleagues discovered some astonishing abilities of NAD+. They found that NAD+ supplements are able to prevent septic shock-induced death. Lipopolysaccharide (LPS) is a bacterial molecule present in organisms such as E. Coli that triggers septic shock. The team started off by administering 40 mg of NAD+ to mice for two days before exposing them to a fatal dose of LPS. Astonishingly, 85% of the NAD+-treated mice survived. On the other hand, all untreated mice succumbed due to the infection within the next 24 hours. This critical finding implies that NAD+ supplements can be a lifeline for preventing death due to septic shock. NAD+: A Powerful Anti-Aging Supplement To dive deeper into the anti-aging effects of NAD+, Iske and his colleagues focused on its ability to curb inflammation in mice. The researchers measured the levels of IL-6 before and after receiving NAD+ treatment. To their surprise, elevated levels of IL-6, resulting from septic shock, were significantly reduced following treatment. This reduction in IL-6 levels hints at the potential of NAD+ supplements to increase survival rates after septic shock by suppressing hyperactive immune responses. Correlation Between Neutrophils and Aging Neutrophils, a kind of white blood cell, are our body’s primary defense against infection. They play a crucial role in resolving infections by seeking out and infiltrating infected organs. However, with aging, this process deteriorates by allowing neutrophils to linger inside organs. This causes organ damage brought on by inflammation. Iske and his team observed that NAD+ administration drastically reduced the infiltration by neutrophils inside the lungs, liver, and kidneys of mice after being afflicted with septic shock. This lesser level of infiltration likely results from a reduced number of neutrophils going inside these organs. Alternatively, there is also a possibility that NAD+ might facilitate neutrophils to migrate out of the body’s organs. Further studies are essential for confirming this promising avenue of research. Overview: Are NAD+ Supplements Worth It? Beyond its potential in preventing septic shock, NAD+ supplementation appears to have far-reaching implications in the realm of aging. Studies conducted using NAD+ nanoparticles have also reached the same conclusion as Iske and his colleagues’ findings by emphasizing NAD+’s role in suppressing inflammation. Additionally, nicotinamide mononucleotide (NMN), a precursor of NAD+, has demonstrated its ability to decrease brain inflammation and enhance memory post-septic shock. These collective results imply that NAD+ supplements might not only safeguard against deadly infections but also counter the aging process by regulating inflammation. All in all, chronic inflammation, stemming from an imbalanced immune system, can significantly contribute to the aging process, a phenomenon aptly termed “inflammaging.” NAD+, as unveiled by the cutting-edge research above, emerges as a potential weapon to fight against inflammaging. These benefits of NAD+ supplements offer a glimpse into a future where aging is met with a strong defense, enhancing both the quality and longevity of our lives. In essence, the discovery of NAD+’s remarkable potential in suppressing septic shock and mitigating the effects of aging marks a significant stride in medical science. As more research is being carried out in this field, the prospect of utilizing NAD+ and its precursors to fortify our immune defenses and defy the ravages of time becomes increasingly more realistic.