Old mice show remarkable enhancements in the activity and functionality of their intestinal stem cells following NMN supplement administration. Stem cells lose their regenerative abilities due to cellular damage, which has significant implications for tissue maintenance and repair. The Lgr5 gene’s reduced activity within ageing intestinal stem cells leads to diminished cell proliferation. This decrease impacts the number of villi and crypts present in the intestines. Thus, reduction in cell proliferation is a key aspect of stem cell ageing. Intake of NMN supplement benefits cell proliferation in aged intestinal stem cells. It does so by elevating cellular levels of nicotinamide adenine dinucleotide (NAD+). NMN also enhances the activity of SIRT1, a protein important for cellular health. Stem cells are the unsung heroes of our bodies. They possess the incredible ability to renew and transform into specialised cells. This capability ensures the continual healing and maintenance of our tissues. However, these remarkable cells are not invincible. Over time, they succumb to cellular damage. Thus leading to their decline and impairing their regenerative abilities—a phenomenon called stem cell ageing. Understanding the intricate processes governing self-renewal, survival of stem cells, and proliferation is pivotal for unlocking the secrets of longevity. Scientists at the Japanese Keio University have made major strides in this pursuit. Their research focused on the diminished activity of a gene called Lgr5 within ageing intestinal stem cells. This decreased activity results in reduced cell proliferation and the activation of genes associated with ageing. In a hopeful turn of events, the scientists found a potential solution to this issue in the form of nicotinamide mononucleotide (NMN). Ageing Shrinks Number of Stem Cells in the Gut The inner lining of our intestines, under the microscope, resembles a landscape of tiny finger-like protrusions called villi. Nestled between these are valleys named crypts. These crypts house the vital intestinal stem cells. Upon drawing a comparison between young and aged mice, the researchers revealed a stark reality. They found that the ageing process leads to a decline in the number of villi and crypts. This information was indicative of decreased cell proliferation during the ageing process, as both villi and crypts rely on continuous cell proliferation for their formation and maintenance. Digging deeper, researchers scrutinised the gene activity within these cells. Their analysis of gene activity pinpointed the culprit—reduced activity of the Lgr5 gene. This gene encodes a protein crucial for cellular mechanisms leading to proliferation. When Lgr5 gene activity dwindles, so does cell proliferation, explaining the diminished number of villi and crypts in the intestines of ageing mice. NMN Supplement Benefits for Aged Intestinal Stem Cells After extensive research and experimentation, NMN has emerged as a potential antidote to stem cell ageing. The Japan-based researchers treated clusters of intestinal stem cells in aged mice, known as organoids, with NMN supplement administration. This experiment led to a remarkable increase in cell proliferation. To achieve this, NMN elevates the levels of NAD+ within cells. It also works to enhance the activity of SIRT1, a protein that safeguards cellular health by regulating molecular tags on proteins and DNA. All of these findings point to the possibility of using NMN to boost cellular levels of NAD+. Using the benefits of NMN treatment can help in enhancing the proliferation of intestinal stem cells. Potential Future Benefits of Nicotinamide Mononucleotide The implications of this research stretch far beyond the confines of the laboratory. As per the researchers involved in the study, the aged animal-derived organoids emerged as invaluable tools. They offer scientists a window into the intricate world of stem cell ageing. These miniature structures provide a platform for scientists to unravel the mysteries of ageing. Furthermore, organoids may also serve in developing interventions to combat the adverse effects of ageing. Overview: Benefits of NMN Supplement for Aged Gut Health As the study’s scientists emphasised, the next step in the quest to crack the code of stem cell ageing lies in validating these findings using human materials. The prospect of applying these discoveries to human stem cells can open the door to a world of innovative treatments. These could significantly extend healthy life expectancy. The journey towards prolonged vitality and well-being has just begun. With every research and revelation, we are inching closer to a future where ageing and the ravages of time will soon become mere obstacles.