Incorporating NMN into hydrogel dressings enhances and accelerates the healing process of skin wounds in diabetic mice. Collagen is a crucial structural protein for both the connective tissues and skin during the healing process. Augmenting the content of NMN for diabetes within the hydrogel dressing leads to a boost in the production and density of collagen in the skin. Amplified concentrations of NMN within the hydrogel dressing result in heightened gene activation. This is related to two proteins vital for skin regeneration, namely TGF-ꞵ and VEGF. People with diabetes face a significant challenge in wound repair. This impaired healing process is even more evident when dealing with foot ulcers in diabetics. The presence of reactive oxygen species (ROS) at ulcer sites hampers the process of wound healing. While clinicians often use dressings as a shield against infection, the efficacy of these treatments remains limited. But that was until a ground-breaking study conducted by researchers from Fudan University in China unveiled a promising solution. Nicotinamide mononucleotide supplement intake is a great remedy to improve overall health. But now, research shows that incorporating NMN, an antioxidant, into hydrogel dressings can also effectively treat diabetic wounds. NMN and Diabetes In their study published in Biomedicine & Pharmacotherapy, researcher Zhu and his colleagues explored the impact of NMN-loaded hydrogel dressings. The researchers wanted to explore the effects of these dressings on diabetic wounds using a mouse model. They discovered that applying hydrogel dressings infused with NMN significantly accelerated the healing process. Wounds treated with NMN-loaded hydrogels resolved approximately 30% faster than those treated with standard hydrogel dressings. Moreover, elevated NMN concentrations lead to heightened gene expression of two critical proteins, VEGF and TGF-ꞵ. Both proteins are involved in the process of skin regeneration. These findings mark a crucial advancement in diabetic wound care, offering hope to millions of individuals affected by the slow-healing process. Nicotinamide Mononucleotide Benefits for Structural Protein Synthesis of Skin One of the key mechanisms behind NMN’s effectiveness lies in its ability to improve collagen production, thereby strengthening the epidermis, the outermost layer of skin, by making it thicker. Zhu and his team compared hydrogel dressing loaded with different NMN doses. They injected mice having a back wound of 1 cm diameter with streptozotocin to induce diabetes. The researchers then administered the NMN-infused hydrogel to the mice. Notably, using higher NMN concentrations accelerated the healing process. Wound resolution with NMN was approximately 30% faster than with hydrogel dressings lacking NMN. Furthermore, the dressings containing NMN also caused the epidermal wall to increase in thickness during healing. This dual action of promoting collagen synthesis and thickening the epidermis contributes significantly to speeding up the healing process. NMN for Diabetes: Effect on Skin Growth-Promoting Proteins To further study NMN’s impact, the researchers analysed the gene activity of essential skin growth-supporting proteins known as VEGF and TGF-ꞵ. The results were astonishing: NMN-loaded hydrogel dressings nearly doubled VEGF gene activity. They also significantly enhanced the gene activity of TGF-ꞵ compared to hydrogels without NMN. This heightened gene activity demonstrates that NMN plays a vital role in accelerating diabetic wound healing by stimulating the production of these key proteins. The significance of this study lies in its pioneering approach. The researchers introduced temperature-sensitive NMN-laden hydrogel dressings as a novel and effective method for promoting the healing of foot wounds in diabetics. Chronic wounds are often harder to treat in diabetic patients compared to non-diabetic individuals. However, the introduction of NMN to wound dressings may revolutionise how we look at diabetic wound care. The antioxidant properties of NMN provide a unique therapeutic advantage, reducing oxidative stress and facilitating a faster healing process. Moreover, this study opens doors to broader applications that extend beyond diabetic wound care. Previous research has indicated that NMN, along with another NAD+ precursor, nicotinamide riboside (NR), promotes healing. The combination of the two precursors has been shown to benefit surface wound healing in old mice. This suggests that NMN could serve as a universal healing agent applicable to various types of wounds. By utilising the power of antioxidants like NMN, medical professionals may transform wound care across different demographics. Thus, the integration of NMN into hydrogel dressings represents a monumental leap in the field of wound care for diabetics. NMN-loaded hydrogel dressings enhance collagen synthesis, increase epidermal thickness, and boost the activity of vital skin-regenerating proteins. All these features offer a potent and affordable solution to expedite diabetic wound healing.