NMN enhances bone growth and size in mice with osteoporosis, an age-linked bone ailment. In cell cultures of human bone, NMN decreases the number of senescence-causing cells. One of the key benefits of NMN for cells of human bones is that it fosters bone development. NMN injections boost bone volume in mice suffering from osteoporosis. As we grow older, our bones become weaker and more prone to fractures over time. However, the existing treatments for this health problem only provide modest increases in bone strength. One big reason for this lack of effective treatments is that we don’t fully understand the root cause of osteoporosis. Osteoporosis is a bone disease that leads to reduced bone density and mass. While the reason for this reduction is not clear, there is still hope on the horizon. And it comes in the form of NMN supplementation. In a recent study published in The Journals of Gerontology: Series A, researchers from the University of Sydney, Australia, have uncovered some exciting findings. The scientists performing NMN supplement research have uncovered its hidden potential to improve bone health. Research work done by Lu and colleagues suggests that the benefits of NMN supplement intake can rejuvenate ageing bone cells. It can also help to heal bones in mice suffering from osteoporosis. This discovery could open doors for NMN supplementation as a promising treatment for this condition. In simpler terms, this study suggests that NMN might be a practical and effective solution for preventing osteoporosis. NMN supplement benefits older individuals with this condition by enhancing their healing capacity. The Science Behind NMN: Targeting Senescent Cells Our bones, like our other body organs, consist of live cells. These cells continually renew and replace old or damaged bone with fresh, healthy bone. However, the number of bone-making cells available diminishes considerably as our age progresses. This decline is partly due to the fact that some of these cells become senescent cells. The senescent cells are unable to generate new bone. This inability contributes significantly to the development of osteoporosis. NMN’s Impact on Bone Volume To examine the healing effects of NMN on osteoporosis, the researchers studied human bone-forming cells, called osteoblasts, in the laboratory. Lu and fellow scientists induced senescence inside the osteoblasts by exposing them to TNF-α. TNF-α is a pro-inflammatory factor, and exposure to it increased the occurrence of senescence in these cells. But when the same cells were treated with NMN, the researchers noted this senescence was reduced nearly threefold. Lu and team’s findings suggest that NMN has the ability to decrease the number of senescent bone-forming cells. The bone-forming osteoblasts transform into matured bone cells called osteocytes. The study’s results showed that when senescence was induced using TNF-α, it caused a reduction in the number of osteocytes. However, the benefits of NMN supplement administration led to an increase in osteoblasts. This strongly implies that NMN supports the formation of new bone tissue. Having observed the positive effects of NMN on bone-forming cells in the lab, the researchers took their experiments to living organisms. They conducted experiments on female mice by removing their ovaries and intentionally breaking the femur bones. This condition mimicked osteoporosis, leading to diminished bone volume. The researchers then injected these osteoporosis-inflicted mice with a 400 mg/kg/day dose of NMN supplement for two months. The result was remarkable – the sick mice showed an increase in bone volume as a result of NMN treatment. Thus indicating that NMN was partially able to reverse the symptoms of osteoporosis. Together with the data from the bone-forming cell study in humans, it becomes evident that NMN is a potential cure for treating osteoporosis by enhancing bone formation. Benefits of NMN Supplement Against Osteoporosis Animal studies in the past have also suggested that NMN may potentially increase bone formation through multiple mechanisms. This includes rejuvenating bone stem cells that are necessary for creating new bone. These stem cells transform into bone-forming cells, and as demonstrated in the study, NMN rejuvenates these cells as well. This collective evidence hints at the possibility that NMN might be able to prevent age-related bone loss. At present, we don’t have studies showing NMN’s direct impact on bone formation in osteoporosis patients. However, the promising results from both human cell studies and animal experiments suggest that NMN could be a powerful ally in the fight against osteoporosis.