Supplementing mice with nicotinamide mononucleotide benefits kidney function and corrects damage by activating longevity-promoting enzymes.When NMN is administered to mice suffering from kidney disease, it decreases the lesions on kidney tissue and reinstates podocytes which are essential kidney cells responsible for waste filtration.NMN supplementation activates an enzyme that promotes long-term health, Sirtuin-1, to suppress damage to kidney cells. Kidneys are a vital organ of the renal system, filtering out unwanted waste and toxic materials from the bloodstream. However, as our age progresses, these organs undergo changes that impair their proper functioning. This age-related kidney dysfunction, better known as glomerulosclerosis, leads to proteins escaping into the urine, resulting in various health complications. For the treatment of such severe cases of kidney dysfunction, procedures like kidney transplants and dialysis are a necessary requirement. In addition to being physically demanding, the current kidney treatments are also expensive, thus leaving room for better alternatives. Thankfully, a recent study published in Scientific Reports offers hopeful insights into a potential solution that may slow down the advancement of this disease for good. Benefits of NMN in Kidney Function Restoration A group of researchers from Japan’s Tokushima University, led by Shu Wakino, used a mouse model to investigate the effects of Nicotinamide Mononucleotide (NMN) on kidney damage. The compound NMN is known for its capacity to boost levels of nicotinamide adenine dinucleotide (NAD+), a molecule necessary for promoting longevity and cell health. After injecting the mice with NMN at a dosage of 500 mg/kg every 24 hours, the study uncovered intriguing outcomes. One of the hallmark issues linked with kidney damage is elevated levels of urinary protein, indicating impaired filtration. The administration of these injections showed that NMN supplements benefit the kidneys by substantially reducing urinary protein levels in the mice. This suggests that treatment with NMN may aid in mitigating kidney damage and improving protein filtration. NMN Kidney Supporting Feature Restores Essential Cells Furthermore, the researchers found that the NMN treatment helped restore the number of podocytes – cells responsible for waste filtration in the kidneys. The mouse model of kidney disease showed a decrease in podocyte numbers. But since the NMN supplement benefits kidney function by increasing podocyte count, it reversed this trend once administered. Activation of Sirtuin-1 and Longevity During the study, NMN also exhibited the capacity to activate the enzyme Sirtuin-1, which is linked to increased longevity. This enzyme’s activation is typically associated with improved health outcomes and is often found at lower levels in age-linked conditions like glomerulosclerosis. Since Sirtuin-1 relies on NAD+ for its function, the researchers investigated how NMN affected Sirtuin-1 levels. The results were remarkable – NMN administration restored the diminished levels of Sirtuin-1 in the mice’s kidneys. Additionally, the study demonstrated that higher levels of Sirtuin-1, facilitated by NMN, played a role in preserving kidney tissue while undergoing damaging Adriamycin treatment. Despite substantial tissue lesions resulting from kidney disease due to Adriamycin, NMN treatment proved effective in mitigating tissue damage, leading to better integrity of tissue structure and overall functional capacity. This groundbreaking research signifies the first exploration into the effects of NMN on a mouse model of glomerulosclerosis. The findings highlight NMN’s potential to combat kidney damage by elevating levels of NAD+ and Sirtuin-1 activation, leading to a restoration of kidney function. Previous studies on NMN’s impact on kidney health have largely focused on its influence on kidney scarring, known as fibrosis. However, this study extends beyond that by demonstrating NMN’s capability to restore the waste-filtering cells of the kidneys, thereby improving overall kidney function. Benefits of NMN for Kidney Disease Currently, dialysis and kidney transplants remain the primary approaches for treating age-related glomerulosclerosis. However, the discovery of NMN’s positive effects opens up exciting new avenues for less invasive treatment options. By harnessing NAD+ metabolites like NMN, it might be possible to treat kidney disease more effectively and with less physical strain, potentially improving the way we address this age-related health challenge. To conclude, the NMN kidney study led by Wakino and his colleagues not only looks at NMN’s potential as a therapeutic solution for age-related kidney dysfunction but also focuses on its role in promoting overall health. As medical research continues to evolve, these findings promise a positive and hopeful future where age-related kidney issues can be more efficiently managed, extending and improving the quality of life of those affected.