In a recent study conducted in rats, researchers have demonstrated that engaging in intense exercise prior to chemotherapy preserves heart function while conserving Nicotinamide mononucleotide (NMN) and nicotinamide adenine dinucleotide (NAD+) levels.The heart-protective effects of exercise were evident as NMN and NAD+ levels remained intact, despite their usual decline following doxorubicin treatment.Adequate NAD+ levels are crucial for cellular energy generation, and high-intensity exercise safeguards cell energy production during doxorubicin treatment. Chemotherapy is renowned for its effectiveness in cancer treatment. However, it certainly doesn’t come without a handful of drawbacks. Among the long list of potential side effects lies the risk of heart injury and cardiac dysfunction. Almost 10% of patients receiving treatment experience cardiac damage due to chemotherapy. Doxorubicin, an anthracycline antibiotic, is extensively used for treating various types of cancerous tumours. But due to its cardiotoxic potential, the chemotherapeutic drug can cause heart dysfunction, leading to heart failure and, ultimately, death for about 50% of those adversely affected. Unfortunately, effective methods to prevent chemotherapy-induced heart damage are currently lacking. However, a recent study has suggested a potential solution – a single high-intensity exercise session before chemotherapy drug administration. Study Highlights and Findings In a recent study conducted on rats, researchers from China investigated the impact of high-intensity exercise on heart health while undergoing chemotherapy treatment. In healthy rats, adequate levels of NAD+ and NMN benefit the heart by supporting proper functioning. However, after doxorubicin treatment, the levels of these compounds plummet considerably. Xing and his colleagues from Qingdao University demonstrated with their research that intense exercise before a chemotherapy session preserves heart function by elevating NMN and NAD+ levels to pre-treatment levels. According to these findings, the heart-protective effects of exercise were evident as NMN and NAD+ levels remained intact, contrary to their expected decline following doxorubicin treatment without rigorous exercise. Thus, while NMN supplements are great for cardioprotection, an intense exercise session can also effectively preserve cardiac function. It counters the adverse effects of doxorubicin treatment by increasing levels of NMN and NAD+, maintaining sufficient cellular energy molecules (adenosine triphosphate or ATP) production. To explore the impact of intensive activity, the experimental group of rats underwent a session of intermittent, intense exercise consisting of four 10-minute intervals of running at a speed of 25 metres per minute just 24 hours before receiving a doxorubicin dose. Next, they were measured for their ejection fraction (the amount of blood ejected with each pump) following chemotherapy. Generally, ejection fraction percentage falls in rats after exposure to doxorubicin therapy. However, studying the benefit of intense activity revealed remarkable findings. Rats that were made to exercise vigorously showed a higher ejection fraction than those that didn’t. The rodents were able to effectively maintain heart function compared to the control group treated with doxorubicin alone. In conclusion, the exercise session protected cardiac damage and dysfunction induced by doxorubicin by preserving sufficient NMN and NAD+ levels in the heart tissue. NAD+ and NMN Benefits in Cardiac Health NAD+ and its precursor NMN benefit us in many ways, playing crucial roles in various cellular processes, such as energy production and DNA repair. Xing and his team wanted to investigate whether there is a link between intense exercise benefits, NMN/NAD+ levels, and the impact of NMN on heart health. Chemotherapy, particularly doxorubicin treatment, decreases NMN and NAD+ levels in the heart tissue. Nevertheless, Xing discovered that the high-intensity exercise session performed beforehand countered this decline, highlighting its potential cardioprotective effects. Preservation of Cell Energy Production One of the key benefits of exercise was its role in maintaining cellular energy production. Chemotherapy treatments significantly hamper the production of ATP, a molecule essential for cell energy generation. However, the high-intensity exercise performed before doxorubicin treatment restored ATP production, further supporting the notion that exercise could preserve heart health during chemotherapy. NMN Benefits and High-Intensity Exercise In short, maintaining abundant levels of NAD+ and NMN benefits cardiovascular health. While NMN supplement benefits are undeniable, the novel study provides compelling evidence that a single high-intensity exercise session before chemotherapy can preserve heart function and counteract chemotherapy-induced cardiac injury in rats. The protective effects are attributed to increased NMN and NAD+ levels, essential for maintaining cellular energy production. This promising research marks the beginning of a potential journey towards safeguarding the heart during chemotherapy and significantly improving patient outcomes.