NMN supplementation increased exercise endurance and enhanced aerobic capacity in adult runners. NMN improves the ability of skeletal muscles to utilise oxygen for energy production during endurance exercise. Doses of NMN up to 1200 mg/day were well tolerated, with no adverse effects noted in middle-aged runners. The most substantial improvements in oxygen utilisation and aerobic power were observed at 600 and 1200 mg/day dosages of NMN. Joining NMN and exercise routines may improve performance and endurance over time. Nicotinamide mononucleotide (NMN) has captured the scientific community’s interest for its potential to enhance athletic performance. Predominantly studied in rodents, NMN exercise supplements have demonstrated promising results in increasing physical endurance and improving energy production at a cellular level. The potential health benefits of nicotinamide mononucleotide have led to a burgeoning interest in understanding how NMN exercise could translate to human performance. The relationship between NMN supplementation, aerobic capacity, and skeletal muscle efficiency stands at the forefront of this inquiry. As a result, it set the stage for comprehensive human trials to uncover the extent of NMN’s benefits in athletic performance. Investigating NMN: A Study on Adult Runners To explore the impact of NMN on human athletic performance, Hu and colleagues conducted a comprehensive study at Guangzhou Sport University. The population of adult runners was selected to find NMN’s effects on aerobic capacity and skeletal muscle efficiency. The study aimed to assess the benefits and safety of NMN supplementation. Participants were divided into three groups to discover the benefits of the NMN supplement, each receiving a different dosage of 300, 600, or 1200 mg/day. These dosages were administered orally in NMN powder over six weeks. During this time, participants maintained a rigorous training regimen, engaging in endurance exercises five to six times weekly for 40-60 minutes each session. Effects Of NMN On Exercise Post-supplementation, participants underwent cardiopulmonary exercise testing to gauge the impact of NMN on their bodies. The testing of nicotinamide mononucleotide benefits focused on the body’s ability to absorb and deliver oxygen to tissues, aerobic power, and the ventilatory threshold. These metrics are crucial in understanding an athlete’s endurance and their energy production during prolonged physical activity. The results of the study on NMN supplement benefits were revealing. Participants receiving the 600 and 1200 mg/day dosages of NMN showcased significant improvements in oxygen utilisation and delivery. Their aerobic power also showed marked enhancement compared to the control group. Notably, the ventilatory threshold at which breathing becomes disproportionately rapid in relation to oxygen absorption improved at these higher NMN dosages. This finding it indicates a heightened efficiency in the body’s respiratory response to intense exercise. In terms of safety, NMN benefits demonstrated an impressive profile. Participants across all dosage groups reported no detrimental physical events, affirming the tolerability of NMN. Heart examinations and exercise testing further supported these findings, showing no abnormalities and attesting to the safety of NMN supplementation. Enhancing Aerobic Capacity and Muscle Efficiency The study by Hu and colleagues delved into the effects of NMN exercise supplements on aerobic capacity. With a particular focus on its implications for exercise. Aerobic capacity refers to the body’s ability to take in, transport, and utilise oxygen during prolonged physical activity. Muscle efficiency, on the other hand, pertains to the ability of muscles to use the available oxygen for energy production effectively. The research on NMN and exercise led to an increase in aerobic capacity among adult runners. Participants receiving 600 and 1200 mg/day doses of NMN showed substantial improvements in their body’s oxygen absorption and delivery capabilities. The enhancement in aerobic capacity highlighted the potential benefits of NMN in exercise and athletic training. Besides aerobic capacity, the study highlighted NMN’s role in improving skeletal muscle efficiency. The ability of muscles to effectively utilise oxygen for energy production is crucial during endurance sports. NMN supplementation enhanced this capacity. This improvement in muscle efficiency contributes to prolonged endurance and better performance during exercise. NMN Supplementation: A New Horizon for Athletic Training Hu and colleagues’ groundbreaking study at Guangzhou Sport University unveiled the substantial benefits of NMN supplementation. The supplements had a positive impact on enhancing athletic performance, specifically endurance sports. Through research and rigorous testing on adult runners, the study demonstrated that NMN supplements improve aerobic capacity. As the body’s ability to utilise oxygen during exercise increases, the athletes optimise their skeletal muscle efficiency for energy production. Participants who received higher doses of NMN exhibited marked advancements in endurance and overall exercise performance, all while maintaining an impeccable safety profile. These findings validate the potential of NMN in elevating athletic prowess and position NMN supplements as a promising adjunct to training regimens.