Faecal matter transplants (FMT) from mice receiving NR treatment also suppress the increase in body weight.
NR-treated mice show higher levels of NADH (type of NAD+) in their faecal matter.
Obesity is a widespread concern linked to a range of age-related ailments. These include but are not limited to heart disease, type-2 diabetes, and cancer. Obesity is most common among older individuals and those living in the West. For those dealing with the challenges of traditional weight management methods such as calorie restriction and exercise, researchers at the Medical College of Wisconsin have found a potential solution: nicotinamide riboside supplements. Their discovery shows how NR could be a new hope in the fight against weight gain. NR is largely reshaping the landscape of gut bacteria.
NR Guards Against Excess Weight Gain
In their study published in mSystems, Lozada-Fernandez and her colleagues embarked on a quest to explore the benefits of nicotinamide riboside for weight control. They especially focused on NR in the context of a diet high in fats. They observed the mice on a high-fat diet, boosted with NR, showed notably less weight gain compared to those who received no NR. This revelation opens up a promising new avenue for managing obesity.
Gut Bacteria Is the Culprit Behind Weight Gain
The connection between gut bacteria and obesity is well-established. Our gut microbiome plays a pivotal role in our physiological processes, including weight regulation. Acknowledging this link, the researchers looked at whether NR’s weight-reducing effects were tied to changes in the composition of gut bacteria.
To test their theory, they transplanted faecal matter from mice treated with NR into untreated mice. All of the latter were on a high-fat diet. To their astonishment, the untreated mice that received NR-treated faecal matter exhibited reduced weight gain. This echoed the results seen in the NR-treated mice. It suggests that NR’s ability to combat weight gain may be connected to its capacity to enhance calorie-burning efficiency and elevate faecal matter NADH levels.
Efficiency in Calorie Combustion
The investigators further discovered that mice receiving NR-conditioned faecal matter transplants did not consume less food or absorb fewer calories compared to their counterparts. Nevertheless, they displayed a significant improvement in energy efficiency. And thus showed a slower weight gain per calorie absorbed. Essentially, the mice benefiting from NR-supplemented faecal matter burned calories more effectively, leading to reduced weight gain.
Unlocking the Enigma of NADH Elevation
Lozada-Fernandez, along with her team, uncovered a fascinating clue: the presence of elevated NADH (NAD+’s reduced type) in the NR-treated mice’s faecal matter. This revelation raises intriguing questions about the mechanisms underlying NR’s weight-reduction properties. The precise workings, however, remain a mystery. It’s uncertain whether NR-conditioned gut bacteria release beneficial molecules that aid in losing weight when exposed to higher NAD+ levels. Or if they directly boost NAD+ levels throughout the body.
Nicotinamide Riboside Benefits for Obesity
The study’s findings underscore the potential of NR as a tool in the battle against weight gain triggered by a diet high in fats. Previous research, including studies on female mice, has hinted at NR’s ability to reduce fat mass and contribute to healthier body composition. Additionally, NR supplementation has shown promise in improving fertility issues associated with obesity in mice. Another precursor of NAD+, nicotinamide mononucleotide (NMN), has demonstrated its potential in addressing fertility problems linked to obesity. The common thread in these findings is that the elevation of NAD+ levels may stimulate increased metabolism of fat cells.
Translating to Real-World Impact
While animal studies have highlighted NR’s potential as an anti-weight gain agent, human trials have produced mixed results. Nonetheless, this study has showcased NR’s potential in tackling obesity among adults. This study revealed that NR supplementation reduced fat while increasing lean muscle mass in obese individuals. Discrepancies between mouse and human studies can be attributed to differences in the composition of gut bacteria, which can influence how NR metabolises and subsequently impacts its effectiveness in increasing body-wide NAD+ availability.
In conclusion, the research conducted by Lozada-Fernandez and her team shines a hopeful light on the potential of nicotinamide riboside (NR) as a tool for managing obesity. By reshaping the landscape of gut bacteria and enhancing calorie-burning efficiency, NR offers a promising path for individuals facing weight management challenges. While further human studies are essential to fully grasp NR’s effectiveness in tackling obesity, these findings ignite hope in the ongoing battle against this global health concern.
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Nicotinamide Riboside is a Gut-Healthy Game Changer in the Battle Against Obesity
Obesity is a widespread concern linked to a range of age-related ailments. These include but are not limited to heart disease, type-2 diabetes, and cancer. Obesity is most common among older individuals and those living in the West. For those dealing with the challenges of traditional weight management methods such as calorie restriction and exercise, researchers at the Medical College of Wisconsin have found a potential solution: nicotinamide riboside supplements. Their discovery shows how NR could be a new hope in the fight against weight gain. NR is largely reshaping the landscape of gut bacteria.
NR Guards Against Excess Weight Gain
In their study published in mSystems, Lozada-Fernandez and her colleagues embarked on a quest to explore the benefits of nicotinamide riboside for weight control. They especially focused on NR in the context of a diet high in fats. They observed the mice on a high-fat diet, boosted with NR, showed notably less weight gain compared to those who received no NR. This revelation opens up a promising new avenue for managing obesity.
Gut Bacteria Is the Culprit Behind Weight Gain
The connection between gut bacteria and obesity is well-established. Our gut microbiome plays a pivotal role in our physiological processes, including weight regulation. Acknowledging this link, the researchers looked at whether NR’s weight-reducing effects were tied to changes in the composition of gut bacteria.
To test their theory, they transplanted faecal matter from mice treated with NR into untreated mice. All of the latter were on a high-fat diet. To their astonishment, the untreated mice that received NR-treated faecal matter exhibited reduced weight gain. This echoed the results seen in the NR-treated mice. It suggests that NR’s ability to combat weight gain may be connected to its capacity to enhance calorie-burning efficiency and elevate faecal matter NADH levels.
Efficiency in Calorie Combustion
The investigators further discovered that mice receiving NR-conditioned faecal matter transplants did not consume less food or absorb fewer calories compared to their counterparts. Nevertheless, they displayed a significant improvement in energy efficiency. And thus showed a slower weight gain per calorie absorbed. Essentially, the mice benefiting from NR-supplemented faecal matter burned calories more effectively, leading to reduced weight gain.
Unlocking the Enigma of NADH Elevation
Lozada-Fernandez, along with her team, uncovered a fascinating clue: the presence of elevated NADH (NAD+’s reduced type) in the NR-treated mice’s faecal matter. This revelation raises intriguing questions about the mechanisms underlying NR’s weight-reduction properties. The precise workings, however, remain a mystery. It’s uncertain whether NR-conditioned gut bacteria release beneficial molecules that aid in losing weight when exposed to higher NAD+ levels. Or if they directly boost NAD+ levels throughout the body.
Nicotinamide Riboside Benefits for Obesity
The study’s findings underscore the potential of NR as a tool in the battle against weight gain triggered by a diet high in fats. Previous research, including studies on female mice, has hinted at NR’s ability to reduce fat mass and contribute to healthier body composition. Additionally, NR supplementation has shown promise in improving fertility issues associated with obesity in mice. Another precursor of NAD+, nicotinamide mononucleotide (NMN), has demonstrated its potential in addressing fertility problems linked to obesity. The common thread in these findings is that the elevation of NAD+ levels may stimulate increased metabolism of fat cells.
Translating to Real-World Impact
While animal studies have highlighted NR’s potential as an anti-weight gain agent, human trials have produced mixed results. Nonetheless, this study has showcased NR’s potential in tackling obesity among adults. This study revealed that NR supplementation reduced fat while increasing lean muscle mass in obese individuals. Discrepancies between mouse and human studies can be attributed to differences in the composition of gut bacteria, which can influence how NR metabolises and subsequently impacts its effectiveness in increasing body-wide NAD+ availability.
In conclusion, the research conducted by Lozada-Fernandez and her team shines a hopeful light on the potential of nicotinamide riboside (NR) as a tool for managing obesity. By reshaping the landscape of gut bacteria and enhancing calorie-burning efficiency, NR offers a promising path for individuals facing weight management challenges. While further human studies are essential to fully grasp NR’s effectiveness in tackling obesity, these findings ignite hope in the ongoing battle against this global health concern.