Inhaling air pollutants brings about lung injury and inflammation by lowering nicotinamide adenine dinucleotide (NAD+) levels. Nonetheless, countering this risk is possible through the administration of NMN, a precursor to NAD+, which effectively prevents lung damage and inflammation in mice. Exposure to air pollutants, particularly particulate matter (PM), causes a substantial drop of 39.86% in lung NAD+ levels. This decline is most likely a catalyst for inflammation, which in turn triggers lung injury. Introducing nicotinamide mononucleotide (NMN) before and during PM exposure acts as a protective measure, averting detrimental lung injury. NMN supplements’ benefits include diminishing elevated TNF-ɑ levels caused by PM exposure, further confirming its ability to safeguard against inflammation. Air pollution is a concerning issue for all humankind. Urban inhabitants, especially, encounter bits of solid and liquid mixtures of pollutants known as particulate matter (PM) from sources like factories and vehicle emissions. With a staggering 80% of the US population living in urban cities, the repercussions of PM inhalation can be severe. Long-term exposure to PM can lead to lung injury and even immune system suppression. Although antioxidants like vitamins C and E have been suggested to mitigate PM’s impact on human health, more efficient methods to prevent progressive lung injury are necessary. Benefits of NMN In Lung Protection Chen and associates from China’s Sun Yat-sen University conducted an insightful study that exposes the benefits of NMN’s potential to counteract lung injury induced by air pollutants. By subjecting mice to high levels of PM for an extended period, the researchers successfully demonstrated that PM exposure significantly depletes the levels of NAD+ in the lungs. This decline in NAD+ sparks inflammation in the body and subsequent lung injury. The study also investigates the efficacy of the intake of NMN supplements in mitigating these adverse effects. Administering the supplement before and during PM exposure proved NMN benefits not only in preventing NAD+ level depletion but also in alleviating lung injury. The connection between NMN and NAD+ levels suggests that NMN’s role lies in maintaining NAD+ levels, which, in turn, inhibits inflammation and safeguards lung health. NMN Reduces Inflammation Delving deeper, the researchers explored the impact of NMN supplementation on inflammation. Chen and team tested if high PM exposure affects NAD+ levels and causes lung injury. After subjecting the mice to 16 weeks of high PM levels in a chamber, NAD+ levels were checked in various tissues. Results: NAD+ dropped in the lungs by 39.86%, in the liver by 37.28%, and in the spleen by 41.20%. The results suggest PM exposure lowers NAD+ and partially contributes to lung harm. For further research, Chen and colleagues wanted to test countering PM lung injury with NMN in drinking water (500 mg/kg/day). They began NMN supplementation two weeks before PM exposure, for 18 weeks total. The outcome showed that NMN prevents severe PM-induced lung injury. China-based scientists aimed to verify NMN’s role in reducing PM-triggered lung injury through inflammation control. They assessed TNF-ɑ levels in blood plasma, discovering PM exposure doubled TNF-ɑ content. The study unveiled that administering the mice with NMN significantly reduced elevated TNF-ɑ levels provoked by PM exposure. This provides strong evidence of NMN’s anti-inflammatory properties, effectively halting the progression of events leading to lung injury. Implications for Public Health: Urban dwellers are particularly vulnerable to air pollution’s detrimental effects. The study’s results propose that the benefits of NMN supplementation could offer a practical strategy to mitigate the consequences of air pollutants on lung health. Additional research demonstrates that NMN safeguards skin cells from PM-related harm. These findings together offer proof of NMN’s multi-organ defence against environmental pollutants. While these studies’ findings are encouraging, it’s essential to acknowledge certain limitations. The researchers primarily focused on demonstrating NMN’s effectiveness in preventing lung injury and inflammation. Further studies could delve into the mechanisms behind NMN’s action, providing a more comprehensive understanding of its role in maintaining lung health. Moreover, the study employed animal models, and translating these findings to humans necessitates robust clinical trials. The potential of NMN supplementation as a preventive measure against air pollutant-induced lung injury opens up avenues for future research. NMN Rescues Lungs from Air Pollution Air pollutants, including particulate matter, lead to lower NAD+ levels, inflammation, and lung injury. However, the study conducted by Chen and colleagues showcases the potential of NMN supplementation in averting these adverse effects. By maintaining NAD+ levels and curbing inflammation, NMN emerges as a promising shield against air pollution’s impact on lung health. This research provides valuable insights into developing preventive strategies against the escalating health threats posed by air pollutants, particularly for urban populations.