Mice stressed in early years show social behaviour deficits and excessive fat accumulation later in life. Deficiency of NAMPT in blood and adipose tissue, a NAD+-producing enzyme, is related to early-life stress and decreased sociability. Nicotinamide mononucleotide (NMN) treatment, a NAD+ booster, can stop the deterioration of brain function and sociability. Childhood obesity is known …
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